The Hippo-TAZ axis mediates vascular endothelial growth factor C in glioblastoma-derived exosomes to promote angiogenesis

Glioblastoma (GBM) is one of the most highly vascularized human cancers. The role exosomes in cancer angiogenesis has attracted recent interest. However, proangiogenic biomolecules transported by to facilitate GBM have not yet been identified. Here, we found a specific 120-kDa isoform vascular endothelial growth factor (VEGF) GBM-derived and confirmed it as VEGF-C. By binding VEGF receptor 2 (VEGFR2), VEGF-C from showed strong stimulatory effect on tafazzin (TAZ) expression cells inhibiting Hippo signaling pathway, which eventually stimulates cell viability, migration, tubulation. In glioma samples, tumor positively correlated with TAZ cells. We further demonstrated that an inhibitor exosomal release had cooperative inhibitory bevacizumab xenograft subcutaneous angiogenesis. Taken together, our findings revealed novel highlighted importance recognizing its unique pathway when considering drug treatment strategies for GBM.